Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2015 | Crewe | 0 | 0 | Port Vale | D Whitestone |
| 15/08/2015 | Port Vale | 1 | 1 | Gillingham | F Graham |
| 18/08/2015 | Swindon | 2 | 2 | Port Vale | B Malone |
| 22/08/2015 | Port Vale | 3 | 0 | Doncaster | R Lewis |
| 29/08/2015 | Bradford | 1 | 0 | Port Vale | J Simpson |
| 12/09/2015 | Port Vale | 3 | 2 | Wigan | M Haywood |
| 15/09/2015 | Port Vale | 0 | 2 | Millwall | O Langford |
| 19/09/2015 | Bury | 1 | 0 | Port Vale | D Drysdale |
| 26/09/2015 | Fleetwood Town | 1 | 2 | Port Vale | S Stockbridge |
| 29/09/2015 | Port Vale | 1 | 1 | Oldham | K Johnson |
| 03/10/2015 | Port Vale | 2 | 1 | Sheffield United | G Salisbury |
| 10/10/2015 | Southend | 1 | 0 | Port Vale | I Williamson |
| 17/10/2015 | Port Vale | 1 | 1 | Peterboro | R Clark |
| 20/10/2015 | Colchester | 2 | 1 | Port Vale | D Deadman |
| 24/10/2015 | Burton | 2 | 0 | Port Vale | D Coote |
| 31/10/2015 | Port Vale | 2 | 0 | Shrewsbury | D Handley |
| 14/11/2015 | Barnsley | 1 | 2 | Port Vale | T Harrington |
| 21/11/2015 | Port Vale | 3 | 2 | Chesterfield | M Bull |
| 24/11/2015 | Port Vale | 2 | 0 | Blackpool | D Webb |
| 28/11/2015 | Rochdale | 2 | 1 | Port Vale | D England |
| 12/12/2015 | Port Vale | 1 | 1 | Scunthorpe | L Collins |
| 20/12/2015 | Walsall | 2 | 0 | Port Vale | K Wright |
| 26/12/2015 | Coventry | 1 | 0 | Port Vale | R Lewis |
| 28/12/2015 | Port Vale | 1 | 0 | Bury | J Adcock |
| 09/01/2016 | Blackpool | 0 | 1 | Port Vale | S Stockbridge |
| 17/01/2016 | Millwall | 3 | 1 | Port Vale | A Davies |
| 23/01/2016 | Port Vale | 1 | 1 | Bradford | L Swabey |
| 26/01/2016 | Doncaster | 1 | 2 | Port Vale | G Eltringham |
| 30/01/2016 | Wigan | 3 | 0 | Port Vale | D Drysdale |
| 02/02/2016 | Port Vale | 1 | 0 | Swindon | P Bankes |
| 07/02/2016 | Port Vale | 1 | 1 | Coventry | P Gibbs |
| 13/02/2016 | Port Vale | 0 | 0 | Fleetwood Town | C Breakspear |
| 20/02/2016 | Sheffield United | 1 | 0 | Port Vale | B Toner |
| 26/02/2016 | Port Vale | 3 | 1 | Southend | A Haines |
| 01/03/2016 | Oldham | 1 | 1 | Port Vale | D Handley |
| 05/03/2016 | Port Vale | 2 | 0 | Colchester | J Simpson |
| 12/03/2016 | Peterboro | 2 | 3 | Port Vale | D Bond |
| 19/03/2016 | Port Vale | 0 | 4 | Burton | E Ilderton |
| 25/03/2016 | Shrewsbury | 1 | 1 | Port Vale | M Heywood |
| 28/03/2016 | Port Vale | 0 | 1 | Barnsley | S Duncan |
| 02/04/2016 | Chesterfield | 4 | 2 | Port Vale | K Wright |
| 09/04/2016 | Port Vale | 3 | 0 | Crewe | P Tierney |
| 16/04/2016 | Gillingham | 0 | 2 | Port Vale | R Joyce |
| 23/04/2016 | Port Vale | 4 | 1 | Rochdale | N Kinseley |
| 30/04/2016 | Scunthorpe | 1 | 0 | Port Vale | B Toner |
| 08/05/2016 | Port Vale | 0 | 5 | Walsall | N Miller |